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I have another Mirapex disappointment story to share with those who are interested. I was doing Ok on Sinemet 25/100 5-6 times per day and 3 Permax .25 per day. I decided to try the Mirapex as it had been so highly praised. I grradually weaned off of the Permax and onto the Mirapex. As soon as the Permax was completely out my system, I began having pretty severe "off times" when I could barely function. I got stiffer than I have ever and had a terrible time turning over in bed. All in I am pretty discouraged and wishing I had never tried it.. I am praying that getting back on Permax will take care of these set backs. Marty [log in to unmask]