Hi friends ! Thank you all for your responses ! I wish I could get my dad logged in so he could "talk" to you in person. This was not a good weekend for him - he still feels so sick and depressed. I managed to get him time with the family physician - who at least assured him that he's "not really sick" ... I mean that he has nothing to worry about even though he feels sick - that its side effects from pills - dpression /worry etc. Of course that didn't really make him feel better. The Dr give him Prilosec to help ease the nauseous stomach - maybe that will help. He assures us that PD and depression are linked - if your brain chemistry is messed up ... it effects other brain chemistry. Made sence ... Now I have more ?'s ... I mentioned that he was on Serzone - I thought it was helping - but my mom read something about too much SSRI's with PD not being good (although I know different ones are different - I know Buspar for example can block dopamine - but she just lumps them all together). Anyway she cut back one of his Serzone thinking this would ease his upset sick stomach and the fogginess he gets ... one less pill couldn't matter that much ? I think it did - I think he's much more depressed than before. I'm interested in the SSRI-syndrome business ... are SSRI's good for PD or not ? I've read that they can be slight dopamine receptor agonists - which is good right ? I think I've read that Mirapex seems to help depression too ? Anybody with any info on anti-depressants ? What about Mirapex and AD ? Anyone read anything about any interactions ? Too many questions ! I'm tempted to call the makers of Mirapex - want to get this sorted out before he goes on it (probably next week ... I've called the "drug info hotline" for Serzone and I hate to admit it (since its the company i work for) but they were pretty useless ! I'm still following other leads ... I'll post any info I find. Thanks in advance for info donna ------------------------------------------------------------------------------ - Donna Bassolino-Klimas, Ph.D. Bristol Myers Squibb Pharma. Res. Inst. Department of Macromolecular Structure P.O. Box 4000 Room H3812 Princeton, N.J. 08543 4000 (609) 252 4413 INTERNET: [log in to unmask] ------------------------------------------------------------------------------