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Donna et al- I am a psychiatrist and have used virtually all of the antidepressants clinically. Nefazodone (Serzone) came out toward the end of my active practice. I was not impressed regarding the efficacy of the drug which I used as a second or third line drug when other drugs had failed. Therefore My sample was skewed with mainly treatment resistant patients getting the drug from me. It apparently is similar to trazodone which I never felt was a good antidepressant in doses that patients were able to tolerate. (Sedation is a significant problem). I believe that was a problem for some of my patients with Serzone as well. I am not aware of any advantages that Serzone has over the others. Charlie CHARLES T. MEYER, M.D. Middleton, WI [log in to unmask]