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I am 59 yrs. old 12+ yrs parkinsons I have tried almost all fda approved meds to improve my pd symptoms and avoid the disabling affects of long term use Sinemet. I followed Pallidotomy Surgery reports for quite some time and discovered that this operation offered significant relief for my uncontrolled movements,wreathing and tight muscles. My neurologist referred me to Neurosurgery at the University of Minnesota where a bi level pallidotomy was recommended. I had one side done in February of 96 and the other side in October of 96. These surgeries resulted in significant improvement Almost eliminating all uncontrolled movements. giving me back better mobility and balance I'm now in my 7th week on merapex.I "m getting longer on times but haven't realized much help on being able to reduce my sinemet. My sinemet dose is still at looo to 1200 mg a day I've been a reader of the Parkinson digest for some time mow thanks to a friend and greatly appreciate the efforts of the regular participants thank you all for sharing your experiences. don't give up,find a cure. best wishes to all.