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I was diagnosed with PD in 1995 at the age of 66. Went on Sinamet CR(250-300 mg / day). The Sinamet gave me horrific nightmares and sleep interruption. This was corrected by taking Melatonin nightly. While the Sinamet helped with many of my PD symptoms, it did not improve my fatigue and depression. I began a daily pill of DHEA (25mg/day). This gave me some relief (20%) with my fatigue and depression. At the same time I went on a vitamin suppliment program. Yikes!!!! This is the person that heretofore would not take even an aspirin, but a desperate situation calls for desperate measures. About 1 month ago, I started taking NADH (5mg/day). I noticed a real increase in my energy level immediately. After three weeks I increased the dosage to 7.5mg/day. As a result of this, I was able to reduce my Sinamet to 1.5 mg/day. Great, (I worry about Sinamet side-effects) To anyone out there taking NADH for PD, please let me know your findings. With Thanks, Gil Gaudry