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------ =_NextPart_000_01BCC385.442567A0 Content-Type: text/plain; charset="us-ascii" Content-Transfer-Encoding: quoted-printable I'm very glad that I can to help you. How I wrote last week , In Argentine in this moment is The XVIth World = Congress of Neurology. Today, it was the presentation about Tasmar. There was an interesting lecture (COMT Inhibition: Overview of clinical = data with Tolcapone in non- fluctuating and fluctuating Parkinson's = disease patients. Wolfgang Oertel Philips-University, Marburg, Germany) In this lecture the speaker said that: "Long-term clinical trials with Tolcapone, a new COMT inhibitor, have = demonstrated clinically significant improvements in symptom control and = ON-time, as well as good tolerability, when used as an adjunct to = levodopa/DCI in both non-fluctuating and fluctuating PD patients. Four = double-blind, placebo-controlled trials and one open-label = active-controlled trial have evaluated orally administrered tolcapone = (100mg tid and 200 mg tid) for up to 12 months in over 1000 PD patients = (298 non-fluctuating, 740 fluctuators). The majority of adverse events = observed were dopaminergic in nature, being attributable to an increase = in the bioavailability of levodopa. The most frequent dopaminergic = adverse event was dyskinesia on initiation of tolcapone therapy = especially in patients who had previously experienced (peak dose) = dyskinesia and/or received at baseline a daily levodopa dose larger that = 600 mg. However, this side effect was controlled in most patients by = rapid levodopa adjustment. The most severe non-dopaminergic adverse = event attributable to tolcapone was diarrhoea, whic led to withdrawal in = 5% and 6% of patients receiving tolcapone 100mg tid and 200mg tid, = respectively, compared with 1% receiving placebo." Beside this, I want to say to you that the Tasmar is being sold in = argentine from yesterday. The cost is U$S 78 100mg (30 Pills) (for 10 = days because three pills for day) up to US 185 200mg (60 pills). I wait that this information is very useful for you. PD: In the message previous I had not any attachment, I don't understand = what happen. 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