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The Patient's Guide mentions a number of possible side effects: dizziness, nausea, sweating, fainting which is caused by it being hypotensive producing; hallucinations and "may make you sleepy". The drug package insert (you can ask your pharmacist for this insert) gives some numbers: out of 260 patients, 53 suffered hypotension, 47 dyskinesea, 27 insomnia, 26 dizziness. Everything else was significantly less. Re: Drug interactions, the insert says essentially no interaction with sinemet, amantadine or eldypryl; other agonists (AJR: like Permax or Parlodel) may decrease the effectiveness of Mirapex; cimetidine caused a 50% increase in Mirapex. Barbara is into her third week and still too early for her to see much of a reaction. She reduced her Permax to zero and is still on the startup low dosages of Mirapex. There have been some positive indications but nothing really significant. I have been logging her experiences and after another week or two I'll give a full report of her reactions. Allan