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On Sun 21 Sep, Barbara Mallut wrote: <<<<I'll never forget a message that was posted here on the List some tim= e ago from the hubby of a woman whose life seemed to revolve around taking her liquid Sinemet. He watched her take more and more of it till there was hardly any time at all between doses. Apparently it's very easy to take a swig a little sooner than one's scheduled to.... and then to take another = swig..... and yet another. And her PD symptoms got worse and worse the more she liquid Sinemet she sipped. Her hubby stressed how very addictiv= e this drug can be to us.>>>> Thanks for the reminder, Barb. I think this is a VERY IMPORTANT topic. = I've discussed liquid Sinemet and the issue of frequent smaller doses of Sinemet vs. less frequent larger doses with two neuro's at the Kansas University Neurological Foundation. Both are widely known PD and moveme= nt disorder specialists who see a number of other List members. My understanding from both conversations is that the body responds more predictably to less frequent larger doses, regardless of the method of administration and that increased dosing frequency often results in more on/off swings. It's therefore easy to understand how LS could become addictive: Every time you crash a swig of Sinemet Gold will fix things in= a few minutes. Of course, each fix exacerbates the problem. I'd like to see more discussion on this "Sinemet dosing frequency" topic and invite List members to discuss it with their docs and report back. = I'll also ask Brian Collins for his comments as he's the resident expert = in this area. Bob Bowling My hands are shakin' and my knees= are weak.... Overland Park, KS = <[log in to unmask]> = Elvis 1957