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Nigel- I think you are asking exactly the right question. I had considered a palidotomy several years ago. I was told that it would make me ineligible for other research procedures. Since then I haVE BEEN A PARTICIPANT IN AN eTACAPONE STUDY AND A FETAL TRANSPLANT STUDY. I made the decision about the palidotomy because some adjustment of my meds at the time made me relatively functional. I am 52 so your caution makes even more sense. If your symptoms are significantly disabling and cannot be significantly improved with a med change, then I would go with the pallidotomy, but if you can waif without sacraficing quality of present if too much I think you would be wise to wait, Charlie Nigel Harland wrote: > > Hello, > AT my most recent meeting with my neuro', he suggested I consider > having a Pallidotomy, which after reading all the various comment from > listmembers, seems like a positive move. However, there is one aspect of > the operation which concerns me,and that is with the advent of the research > into Brain cell regeneration drugs i.e. GPI-1046, would having had a > pallidotomy have an adverse effect on a potential recovery should these > drugs become available? I know that research into GPI-1046 is still in its > infancy, but at the age of 42 I don't want to make a decision now that I > might regret for a long time. > Regards, > [log in to unmask] -- CHARLES T. MEYER, M.D. Middleton, WI [log in to unmask]