Nigel I spoke about tis problem with the neurologists of the university hospial of Amsterdam. They unanimousley said the posiblity of being really cured from Parkinson seemed yet far away. That is why they did the pallidotomy without hesitation. They too said the alectonic inplants are not without risk of damage.Beides to have an inplanted elevrtode heightens the possibility to have an infection in ones brain brcause the blood rain barrier, which protects the brain against bacterias id destroyed for one small place. I felt it was gambling to take the pallidotomy, but the fact that neuro's, who were so carefull wanted to do it helped me to believe it could not be irresponsible. I had before I decided the same doubts as you have. For me thinking that not doing something has it risks too, the risk of spoiling a period of ife without necessity, which can be regretted later in life.My husband and I are both strong and healthy, so we can think about doing some travelling again, wch I would appreciate very much. wanting to do that yet,it seems unwise to weight too long, because rowing older risks of loosig anoherpart of ones health grow. And to enjoy really the travelling and for not feeling all the time deadly tired, in my opinion one should take the chances that one has. I think we can not completely avoid a bit of gambling. IN fact the haevy dyskinesias which I suffered and which are now gone made me very house bound and being nearly always at home is less stimulating and motivating to keep a cetain level of activities. I feel much better in new and interesting places, were I keep moving and because of that the meds do their work better. I understand fully that everyone has to weigh this things for him\herself. Ida Kamphuis Nigel Harland <[log in to unmask]> schreef: > Hello, > AT my most recent meeting with my neuro', he suggested I consider > having a Pallidotomy, which after reading all the various comment from > listmembers, seems like a positive move. However, there is one aspect of > the operation which concerns me,and that is with the advent of the research > into Brain cell regeneration drugs i.e. GPI-1046, would having had a > pallidotomy have an adverse effect on a potential recovery should these > drugs become available? I know that research into GPI-1046 is still in its > infancy, but at the age of 42 I don't want to make a decision now that I > might regret for a long time. > Regards, > [log in to unmask] >