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In a message dated 97-09-25 14:32:37 EDT, you write: << that prolonged use of levodopa "can lead to severe motor fluctuations" ? >> Motor fluctuations are just what I was trying to describe with 'kicking in' and 'kicking off', meaning that one can be almost normal in physical performance, and then the freeze comes on. When ingestion of the next dose is processed by the system and the drug reaches the active sites of the brain, the drug is 'kicking in' again. Our neuro suggested that the intensity of the fluctuations (the levels of the highs and the lows might be reduced with amantidine (Symmetrel). Apparently each muscle of the body is slowed down by the disease and is dependant upon the level of L-dopa active in the brain. Michel Margosis