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During the course of your wife's taking PERMAX did she experience a marked weight gain. Now that she is weaned off PERMAX has there been any difference in her weight assuming that was some gain in the first place. I understand the decrease in excercise from :normal: to PD levels probably does cause it but she certainly watching what she eats (salt substitute and as little fat as possible) plus excercise as much as she reasonable can each day but nothing helps. Plenty of fruits and vegs little red meat all the healthy things but we suspect the PERMAX as the culprit. any ideas?? Chuck for Joyce 53/14 BTW her nuero is not in too much of a rush to start her on this right now. Her symtoms are all in her not being able to move her legs by herself most of time. No tremor and no dyskenesias to mention.