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Hi Mary & all! Decided to include all of you with the following information. Never know when there may be a shy guy/gal in the group who may have an interest. The past five years, I've taken 2 capsules of Midrin plus 1 capsule of a generic called Naproxen (Anaprox) beginning at the first signs of a pending headache. I repeat with 1 Midrin in 1 or 2 hours if necessary. (The key to success is to take both medications at the very first sign.) The Naproxen (500 MG) can be repeated 8 hours later. But since I'm highly sensitive to meds, I never usually have to repeat the Naproxen because my headache usually is gone by then. The only caution and warning I read about Naproxen is: "Do not take Naproxen if you are alergic or sensitive to this drug, Aspirin, or other NSAIDs (One of several nonsteroidal anti-inflammatory drugs used to reduce inflammation, relieve pain, or reduce fever. All NSAIDs share the same side effects and may be used by patients who cannot tolerate Aspirin.) Naproxen may cause stomach ulcers. This drug should not be used by patients with severe kidney or liver disease." The only info I have on Midrin is that it is a brand-name drug containing an analgesic and it's a sedative drug used for migraine. As mentioned, I'm not a PWP. However, the combination of these two prescription drugs works for me. Wishing you a "goodbye to headaches forever". Clara Nistler 62 Gene Nistler 64/11