> ... just switched to Mirapex ... > Well, we made the first major error one makes, we neglected to clarify the > times the Mirapex was to be taken. So, the good patient and CG diligently > made sure the medications were taken on time. Bruce stopped the Permax > cold turkey on Wed evening and began his Mirapex (.l25). He took the drug > WITH his Sinemet and Eldypryl beginning in the am and continuing every 4 > hours. (BIG MISTAKE). > We, thank God, found out that this was completely wrong. He should not > combine the drugs and in addition, the Mirapex must be spaced out about 7 > to 8 hours apart. My dad just switched to Mirapex and his neuro gave him a fact sheet from Upjohn. He was only taking Sinemet (a 1/2 tablet 4 times a day). His N cut him back to three times a day and told him to take it with the Mirapex ! He takes them (0.125mg) 3 times - with breakfast/lunch & dinner. he seems to be doing well with it so far - but he was one who could NOT tolerate Sinemet. People who were happy before don't seem as thrilled with the Mirapex as those who were MISERABLE on Sinemet. > Bruce suffered terribly - chills, insomnia, chest tingling, sluggishness, > slurred speech - you name it. It was terribly frightening. Wow that must have been scary ! > We hope this is the beginning of a positive future with Mirapex. Time, > communication, and a positive attitude all help. > I hope so too - for you AND us ... It amazes me how little is known about the administration of this drug and also how different people react to different regimines ! I guess you have to find whats best for you - but in between when it gets worse before getting better its tough to deal with ! talk to you soon donna (daughter of PD dad 74 dg 1/97 - Sinemet/Mirapex) ------------------------------------------------------------------------------ - Donna Bassolino-Klimas, Ph.D. Bristol Myers Squibb Pharma. Res. Inst. Department of Macromolecular Structure P.O. Box 4000 Room H3812 Princeton, N.J. 08543 4000 (609) 252 4413 INTERNET: [log in to unmask] ------------------------------------------------------------------------------