Well my dad is on Mirapex now - this is day 4 ... He's at 0.125mg 3 times a day. The Neuro cut his Sinemet from 2 tablets (1/2 - four times a day) to 1.5 (1/2 - three times a day). To us he seems a little better - more alert - and less "foggy" ! Actually ASKED for a doughnut the other night and seconds at dinner last night ! The N also told him to walk - walk and walk some more - so he's been trying to. Now he's been saying that his legs feel TIGHT. (Now is original symptoms were pain in his legs - never had much tremor). I'm not sure if what he's feeling now is 1) the same as before (i.e - not enough Sinemet/Mirapex) or 2) - what others of you talked about feeling when you needed to CUT the Sinemet some more or 3) just from more exercize/walking than he's done in MONTHS ! So- if someone could 'splain how you knew you had to cut the Sinemet - maybe I can match it to what my dad it saying. I suppose if it is overmed - we'll find out Monday - when he does to the higher dose of Mirapex. Have a good weekend Donna ------------------------------------------------------------------------------ - Donna Bassolino-Klimas, Ph.D. Bristol Myers Squibb Pharma. Res. Inst. Department of Macromolecular Structure P.O. Box 4000 Room H3812 Princeton, N.J. 08543 4000 (609) 252 4413 INTERNET: [log in to unmask] ------------------------------------------------------------------------------