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After six weeks on Mirapex (slowly weaned off 3 mg. Permax) I am having fewer "off" times and the ones that I have are shorter in duration. I am having no "freezing episodes. I will have to start working on cutting my sinemet dose down to help dyskinesias. (currently I am taking 10-12 sinemet 25/100 mixed in orange juice daily.) At weeks three and four I had slight problem with nausea and headaches. This has resolved. I am taking .75 mg. Mirapex 4 times a day. I only pray that this improvement will continue. Carol Gray [log in to unmask]