Brian Collins mentioned something about Madopar not being as toxic as Sinemet - unfortunately I deleted the post- I would really appreciate learning more about it. I am very concerned with toxic effects of all PD drugs, having taken Sinemet and Sinemet CR for over 10 years, also have long relationship with Eldepryl. I now have a change to reduce Sinemet, Mirapex is working very well for me. But just how toxic is Mirapex? Any of the new dopamine agonist better than the other? I joined the list last Summer, and having been away would like to re-introduce myself. I am 55, PD 10+ years, and I live in Florida. I am truly greatful to have found this amazing group of people. Lisa [log in to unmask]