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I'm also a new subscriber for my husband, John, 63/3 and am thrilled to have found this resource. We live in Virginia and John is still able to work as a builder. His neuro says he is still in the early stages of PD as his symptoms are micrographia (right hand), which has gradually worsened to the point of difficulty in using that hand even to eat, and extreme pain and sometimes cramping in the right arm and wrist. He has been on 5 mg Selegiline twice/day for the three yrs. Just today the neuro has added Mirapex with gradual dosing. I see several posts about difficulties some of you are having with this drug and will continue to watch both John's reaction as well as future posts. Because we are new to the list, is there a universal response from those of you on the drug as to how long the intro period should be and at what doses? This could save a lot of adverse symptoms if so. Also, are there meds or exercises for this constant pain in the right arm and occassional crippling cramping of the wrist? The neuro is baffled. Aleve helps somewhat, but certainly not enough. Thanks for any advice and input that you'll might have. It's good to be here! Nan Boswell - not a caretaker yet!