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I'm not sure if you're aware of this, but SinemetCR has a "Bioavailability" of only about 48%. This just means that your 50/200 tablet was only giving you about 96mg of DOPA. Fatta Date: Sun, 5 Oct 1997 17:21:20 -0400 From: Liisa Millen <[log in to unmask]> Subject: Toxic drugs Brian and others, thanks for responding. I have been taking SinemetCR 50/200 3x, so I guess my carbidopa has been close to the recommended range. I am now up to 1.5mg Mirapex, and have reduced SinemetCR by 1/2, getting 75mg of Carbidopa and 300mg of Sinemet per day. Now the problem is where to go from here, I was instructed to increase Mirapex further, but after reading the possible side effects I am wondering which is worse, Sinemet or Mirapex. I understand dopamine agonists are believed to have some neuroprotective qualities, but there so many thing that scientist disagree on. My level of functioning is adequate now, I have occasional short "off" times, and sometimes mild dyskinesias at peak dose. I found Madopar in my drug book as a combination with benserazide, 200/50 and 100/25. Thanks again, Lisa