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Yen... The only useful thing my very first neurologist (one of several over the years) said to me after he diagnosed my PD over 15 years ago was that to get the best results from the PD drugs available I'd need to experiment by "juggling" dosages around till I found the dosage level that worked well AND gave me the fewest side effects. I'd started out on the Sinemet 25/100 and was ALWAYS nauseous, plus my PD symptoms didn't really change. I switched to Sinemet 25/250s and the nausea stopped and many of the PD symptoms disappeared... but then I also developed some "Sinemet-itis! " (them darn side effects!!). I began reducing the Sinemet 25/250s a bit at a time and tried each level for about 2 weeks or so till I found a level of drug intake that gave me maximum benefits with the fewest side-effects. After a rocky start 4 weeks ago on Mirapex, I started the drug again and followed our Cyber-Bro Ivan's advice and DIDN'T reduce my Sinemet dosage down as I'd initially done when starting Mirapex. And I AM starting to get some beneficial effects from the Mirapex - tho not the magical-wonderful-golly-gee-whiz-I-can't-believe-it results that some others have had. (to be covered under a separate post) Sooooo, m'friend, I suggest that you CONSIDER (i.e., think about it at the very least) experimenting with your daily Sinamet dosage (and possibly the other drugs?), and the dose/frequency with which you take it. Remember - a Parkie's MD doesn't know from moment-to-moment, or day-to-day how we feel anymore than WE do 'cause this disease IS very unpredictable. As IT changes throughout the days and months, to get the maximum benefits from the drugs we take WE have to consider flexing our drug intake to accommodate those changes... In other words - EXPERIMENT. Best of luck to ya in finding a comfortable or at least tolerable PD plateau. Barb Mallut [log in to unmask] ---------- From: Parkinson's Information Exchange on behalf of Yen Hau Sent: Monday, October 06, 1997 3:51 AM To: Multiple recipients of list PARKINSN Subject: How to solve the "ON" and "OFF" problem? I am a twenty-seven year old parkinson patient. I was diagnosed I have this disease two years ago. I have been taken 6 Sinemet 25/100 per day, bromocriptine 2.5mg three time per day, jumex(selegiline) 5 mg one in the mnorning. However, I have this significant "on" and "off" effect happen that influence my daily function. I was forced to resign. Somehow, the sinemt that I took after meal doesn't turn me "on". The side effect, excessive movement cause me a lot of trouble. Does anyone have similar symptons as I do? Please share your experince with me!! Thanks a bunch! Yen ______________________________________________________ Get Your Private, Free Email at http://www.hotmail.com