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^^^^^^GREETINGS FROM^^^^^^^^^^ Ivan Suzman 47/10 [log in to unmask] Portland, Maine land of lighthouses deg. F *********************************************************** On Sun, 12 Oct 1997 09:33:00 -0400 Arlene Walsh <[log in to unmask]> writes: >we need your help. Jim is up to 0.5 tid + his usual dosage of 2 >(25/100)Sinemet every two hours until 7 in evening. His handwriting >is best >it has been in 5 years, he definitely sleeps better, but his speech is >the >worst its ever been and he is more absent-minded with mild >hallucinations. > Would a adjustment of the Sinemet dosage help? Are we overdosed on >Sinemet? > Do we have to ride thru this to get to the other end? Jim's neuro has >no >experience with Mirapex. Jim is his first patient to try it. So we >are all >flying pretty blind. Can anyone with any experience help us out?. >Jim >(62/14) was so discouraged this morning when I told him we might have >to >lower the dosage of Mirapex that he cried in dispair. He was so >hopeful of >this drug. He wants to keep going. >Arlene (caretaker) [log in to unmask] > Dear Arlene, Don't despair!! I was VERY depressed just two weeks ago because Mirapex lowered my blood pressure WAY TOO LOW (80/50), but now, I'm better. I had to learn to take coffee (caffeine) in the morning, and only a small amount o f Mirapex, until after lunch. I'm on .625/day (5 x .125 mg), and am ALSO my neuro's ONLY Mirapex patient. AS FOR SINEMET, I had to cut down 40% /day -which is good -- to avoid wild dyskinesia, sweats, and precipitous end-of-dose crashes. SO, I think reducing at least one of your husband's doses of Sinemet 25/100, aiming to lower his consumption of 1200 mg/day that you describe, is very likely to help. I am down to 800-900 from 1300, and my "on" periods are longer and smoother. Please give your husband a big hug from me, and here is a 'cyberhug' for you: ((((0)))). Yours, IVAN (47/10)