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I am 58/12yrsPk Bi level Palidotomy Feb & oct 96 11 weeks on mirapex I started with .125 mg 3tid and have taken quite some time to reach 1 mg tid. My initial benefits became apparent at 2 of the .125 3tid. My enengy showed definite improvement as did my on times which lengthened to at least 4 hours from 2and a half hrs. The side effects I've noticed are: seem to be hyper and somewhat jittery . Have more energy resulting in faster rate of walking almost to a trot. I've had some new episodes of temporary speech loss slurring of words (thick tongue like) but blame this on some timing irregularities and over activity. )or: it may have been low blood pressure as I've been taking florinef for low blood pressure. I was initially successful in cutting back about 20% of my sinemet daily dose but after increasing the mirapex to 1 mg 3tid I am again taking the same quantity of sinemet. My nero.said he will see if I can cut back after I get adjusted. The main reason for returning to the original sinemet doses is because I was again having trouble sleeping . I cannot determine if this is a situation of the Mirapex making the sinemet more efficient or less efficient. Presently I have good energy now for 6-7 hours of moderate activity and on my routine schedule of sinemet and mirapex 3-4 50/200 CR AND 6-8 25/100 REG. SINEMET. My sinemet dosages are ranging between 1200 mg to 1600 mg daily depending on where I'm at a spacific time during the day and the progress or lack of progress with mirapex. I am presently convinced that mirapes is a good addition to sinemet . October 12, 1997 Robert Langer [log in to unmask]