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On Tue 07 Oct, Lionel R. Modra wrote: > Hi List, > > I have a question regarding the minimum daily amount of Carbidopa > required to gain the benefit from this drug in combination with > Levodopa. My wife, 67/Dx Jan 97, was started on 3 sinemet 100/25, and > then a few months later, Selegiline 2 x 5 mg. (each per day). She > developed some toe cramping about two months ago, and we suspected over > medication, so she has reduced the Sinemet to 2 per day. The toe > cramping has all but disappeared, so it seems that she was over > medicated. This means that she is now getting only 50 mg Carbidopa a > day. However, her PD symptoms are fairly well under contol. > > Regards, > > Win & Lionel Modra > [log in to unmask] > > Hello Win and Lionel, It is good to hear that you are able to manage with such a small dose of levodopa. I certainly wouldn't worry about only getting 50 mg of Carbidopa : All that can happen is that you may lose a bit more levodopa than normal while the drug is in the bloodstream. However, that was the situation when you backed-off to 2 Sinemet per day and found it OK, so you have already come to terms with your Carbidopa levels. Regards, -- Brian Collins <[log in to unmask]>