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Nausea is common with Sinemet. The lack of appetite can also be connected with depression, which is common with Parkinson's. Various medications can help this. My father-in-law's, who is age 86 & diagnosed 1 yr ago, had lost 20 pounds in the year prior to diagnosis. His doctor prescribed Remeron, an antidepressant, which helped him get a good night's sleep and also increased his appetite. After he was established on that, he added Prozac which really helped him feel perkier & happier during the day, & then he began to become involved in many activities. Blessings, Ellen. I know it's difficult to care for someone with PD; & to be the person with PD. Mary Legan 55/5+