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<tr><td align=center>Search for "(Parkinson and HSV)" in <nobr><a href="/server-java/Keysearch?(Parkinson%20and%20HSV)">Medscape's free Full-Text Articles</a></nobr> or <nobr>the <a href="/server-java/MedBookSearch?(Parkinson%20and%20HSV)">Medscape Bookstore</a></nobr></td></tr>
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<dt><B>Title</B>
<dd>Development of an HSV-based vector for the treatment of <b><i>Parkinson</i></b>'s disease.</dd>
<dt><B>Author</B>
<dd>Fink DJ; Poliani PL; Oligino T; Krisky DM; Goins WF; Glorioso JC</dd>
<dt><B>Address</B>
<dd>Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA.</dd>
<dt><B>Source</B>
<dd>Exp Neurol, 144(1):103-21 1997 Mar
</dd>
<dt><B>Abstract</B>
<dd>The restricted pattern of neurodegeneration seen in <b><i>Parkinson</i></b>'s disease, and the identification of trophic factors that prevent toxin-induced degeneration of dopaminergic neurons, has spurred research into potential gene therapy for this disease. Herpes simplex virus (HSV-1) is a neurotrophic virus which naturally establishes latency in neurons. HSV-based vectors have been demonstrated to transfer and transiently express transgenes in neurons in brain in vivo. Recent experiment have shown that deletion of multiple immediate-early HSV genes reduces the potential cytotoxicity of these vectors, and in addition results in altered patterns of transgene expression that may allow for long-term expression required for human gene therapy applications.</dd>
<dt><B>Language</B>
<dd>Eng</dd>
<dt><B>Unique Identifier</B>
<dd>97271208</dd>
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</dd>
<dt><B>MESH Headings</B>
<dd>Gene Expression; Gene Therapy (*); Genetic Vectors (*); Human; <b><i>Parkinson</i></b> Disease (*TH); Simplexvirus (*GE); Trans-Activation (Genetics)</dd>
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</dd>
<dt><B>Publication Type</B>
<dd>JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL</dd>
<dt><B>ISSN</B>
<dd>0014-4886</dd>
<dt><B>Country of Publication</B>
<dd>UNITED STATES</dd>
</dd>
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