Dear friends, I am not currently taking sinemet. However the reason I am not taking the "Traditional" P.D. med is not because of my youth, but because I have been led to believe that I would be non-responsive to it. Having incurred only post-synaptic damage to the globus pallidus, I had been told that more dopamine would make no change in my symptoms. Now, I have been informed by Carole H. that their program for fetal tissue implants requires a positive response to sinemet. Could someone please try to explain to me the physiology of Dopamine? By that I mean, would sinemet help provide dopamine to the basal ganglia? Jacob