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Y'know... I think from now on when I'm asked what college I've graduated from, instead of replying "UCLA," I'm gonna hafta say "Janet Paterson University!" <smile> I'm sure I've learned more due to Janet's informative and interesting posts than I EVER learned in the ivy covered halls of UCLA! THANKS CYBER-SIS! Your time and efforts on behalf of your Cyber-family are really appreciated, as is ht wisdom you share with us. Barb Mallut [log in to unmask] ---------- From: Parkinson's Information Exchange on behalf of janet paterson Sent: Friday, October 10, 1997 5:23 AM To: Multiple recipients of list PARKINSN Subject: PMID: 9268238: Decreased amino acid levels in PD ------------------------------------------------------------------------ Decreased cerebrospinal fluid levels of neutral and basic amino acids in patients with Parkinson's disease. ------------------------------------------------------------------------ We measured the CSF levels of 21, and the plasma levels of 26, amino acids in 31 patients with Parkinson's disease (PD) and in 45 matched controls. We used an ion-exchange chromatography method. When compared to controls, PD patients had lower CSF levels of taurine, alanine, valine, leucine, isoleucine, ethanolamine, citrulline, ornithine, lysine, histidine, arginine, and alpha-aminobutyric acid. PD patients not treated with levodopa or with dopamine agonists had higher CSF tyrosine and phenylalanine levels than those not treated with these drugs and also than controls. PD patients had higher plasma levels of phosphoserine, threonine, methionine, tyrosine, sarcosine and alpha-aminoadipic acid, and lower plasma levels of valine, leucine, and tryptophan, than controls. The CSF/plasma ratio of many of these amino acids was significantly lower in PD patients than those of controls, suggesting that PD patients might have a dysfunction in the transport of neutral and basic amino acids across the blood-brain barrier. J Neurol Sci 1997 Sep 10;150(2):123-127 Molina JA, Jimenez-Jimenez FJ, Gomez P, Vargas C, Navarro JA, Orti-Pareja M, Gasalla T, Benito-Leon J, Bermejo F, Arenas J Department of Neurology, Hospital Doce de Octubre, Madrid, Spain. PMID: 9268238, MUID: 97412125 ---------------------------------------------------------------------------- [log in to unmask]