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Barbara Mallut wrote: > > Y'know... I think from now on when I'm asked what college I've graduated from, > instead of replying "UCLA," I'm gonna hafta say "Janet Paterson University!" > <smile> > > I'm sure I've learned more due to Janet's informative and interesting posts > than I EVER learned in the ivy covered halls of UCLA! > > THANKS CYBER-SIS! Your time and efforts on behalf of your Cyber-family are > really appreciated, as is ht wisdom you share with us. > > Barb Mallut > [log in to unmask] > > ---------- > From: Parkinson's Information Exchange on behalf of janet paterson > Sent: Friday, October 10, 1997 5:23 AM > To: Multiple recipients of list PARKINSN > Subject: PMID: 9268238: Decreased amino acid levels in PD > > ------------------------------------------------------------------------ > Decreased cerebrospinal fluid levels of neutral and basic amino acids > in patients with Parkinson's disease. > ------------------------------------------------------------------------ > > We measured the CSF levels of 21, and the plasma levels of 26, amino acids > in 31 patients with Parkinson's disease (PD) and in 45 matched controls. We > used an ion-exchange chromatography method. > > When compared to controls, PD patients had lower CSF levels of taurine, > alanine, valine, leucine, isoleucine, ethanolamine, citrulline, ornithine, > lysine, histidine, arginine, and alpha-aminobutyric acid. > > PD patients not treated with levodopa or with dopamine agonists had higher > CSF tyrosine and phenylalanine levels than those not treated with these > drugs and also than controls. > PD patients had higher plasma levels of phosphoserine, threonine, > methionine, tyrosine, sarcosine and alpha-aminoadipic acid, and lower > plasma levels of valine, leucine, and tryptophan, than controls. > > The CSF/plasma ratio of many of these amino acids was significantly lower > in PD patients than those of controls, suggesting that PD patients might > have a dysfunction in the transport of neutral and basic amino acids across > the blood-brain barrier. > > J Neurol Sci 1997 Sep 10;150(2):123-127 > Molina JA, Jimenez-Jimenez FJ, Gomez P, Vargas C, Navarro JA, > Orti-Pareja M, Gasalla T, Benito-Leon J, Bermejo F, Arenas J > Department of Neurology, Hospital Doce de Octubre, Madrid, Spain. > PMID: 9268238, MUID: 97412125 > ---------------------------------------------------------------------------- > > [log in to unmask] Hey, wait a minute fellow Bruins! Don't sell Westwood Tech short! Bob Vernon, UCLA '68.