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Hi List, I have a question regarding the minimum daily amount of Carbidopa required to gain the benefit from this drug in combination with Levodopa. My wife, 67/Dx Jan 97, was started on 3 sinemet 100/25, and then a few months later, Selegiline 2 x 5 mg. (each per day). She developed some toe cramping about two months ago, and we suspected over medication, so she has reduced the Sinemet to 2 per day. The toe cramping has all but disappeared, so it seems that she was over medicated. This means that she is now getting only 50 mg Carbidopa a day. However, her PD symptoms are fairly well under contol. She is also taking Ditropan (Oxybutynin HCl)and Tofranil (Imipramine HCl) for an overactive detrusor muscle, and a weak urethral sphincter muscle. We understand that Tofranil, in particular, can interact with selegiline, and boost its effect. Yes, we know Tofranil is one of the drugs that are contra-indicated with MOA inhibitors, but her dosage of Tofranil is only 25mg per day. (Actually she is only taking 20mg per day at present). Ditropan dosage is 15 mg per day. Her urologist has just added the Tofranil, and increased the Ditropan at the end of last week. Win also takes vitamins and supplements. Her sister, 66/19, has always taken vitamins etc, and she still has her PD under reasonable control with 1 x 5 mg selegiline and 3 x 250/25 levodopa/carbidopa daily. We would appreciate any comments. Regards, Win & Lionel Modra [log in to unmask]