I am 58 -12 yrs PK Bi-level palidotomy (Feb and October 1996.) 11 weeks on Mirapex. I started Mirapex at a dose of .125 i tab 3tid. My initial benefits came at a doseage of 2 tabs .25 3 tid. My energy improved as did the length of my on times. and I also felt more alert . . better movement all around. Some of the side effects I've noticed are. 1. temporaqry speech loss episodes(may be due to low blood pressure) 2.confusion zombie like spells between doses. I can avoid these if I eat very light and don't eat red meats. 3.Experienced a hyper or excited feeling starting at 3 tabs .25 mg. 3tid. this seems to be leveling off as I get used to this med. 4.Have low blood pressure from sinemet and mirapex also is known to cause l low blood pressure . I am taking florenef for this. I was successfut in cutting back about 20% of my sinemet daily dose at earlier dosages of mirapex but now find that I have to again resume taking maximum doses of sinemet. My energy and on times have streached to 6-7 hours before I crash to a zombie like off period . Rest and sinemet usually bring me out of this. I take 3 to 4 Sinemet 50/200 CR (6am, 11am, 2 pm and 8pm) 6 TO 8 sinemet 25/100 (6 am,8 am1201 pm,3 pm,5 pm,7 pm 1 am and3am) And 1-1mg mirapex 3 tid (6 am, 1201 pm and 5pm.) My sinemet dosage varies , depending on my activity level and my meals day by day. I normaly take 1200 to 1400 mg of sinemet a day. I am hopeful that mirapex will prove to be effective until something better comes along. I am optimistic that it will prove to be more beneficial as I get the proper timing and doses adjusted on this sinemet mirapex combination. Find the cure for Parkinsons! End.