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Dorothy, To my knowledge there is no data that anesthesia precipitates PD. I think it is natural to try to come up with a theory when something like PD hits an otherwise healthy person out of the clear blue sky. I want to emphasize that I am not saying that it is not possible just that I am not aware of any data which would support it. An alternative theory might be that in the years leading up to your husband's knee replacement his gait subtlety changed causing extra wear and tear on the joint. His surgery could have been the result of early PD rather than its cause. My point is that it is human to speculate and look for a cause but with PD with few exceptions we wind up frustrated. Good luck Charlie dorothy lee wrote: > > My husband Dick had a total knee replacement > in June of l995. Though the operation was a > roaring success, it was shortly thereafter we > bagan to notice the changes in his posture, > behavior, tremor, etc. that were finally diagnosed as P.D. one year > later. If there > a possibility that the PD was there lurking > and the anesthesia for the surgery was some > kind of a trigger? > thanks for any thoughts on this. > Dorothy, cg for Dick 74/1+ in > gorgeous Central New York -- CHARLES T. MEYER, M.D. Middleton, WI [log in to unmask]