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On Fri 17 Oct, WHITIE wrote: > Hi all ; > My mother just started PERMAX at one 0.05 mg. a day, can anyone tell me > if they are using permax, and if it helps much ? > she also takes 3- SINEMET CR 25/100 a day spaced at about 4 hours. > The new neuro that rx'd it, said it will help with, getting up from a chair, and > with the walking problem. I asked for mirapex, but he thinks permax will work > better on the walking problems. WHITIE > [log in to unmask] > > Hello Whitie, I have been using Permax since it first became available, and I am quite happy with its performance. If I have understood your mother's problems, she is showing the signs of insufficient levodopa from her tablets, but if she tries to take more she runs into dyskinesias. If that very brief sunnary is right, then Permax should be ideal. It does the same job as the Dopamine which you get from the Sinemet, but it does not drive you any closer to the dyskiesia area. The way that I use it is : First I worked up to a doseage of Permax which gave me a comfortable margin and I could get about easily. - That was three of the 250 microgramme tablets (Your mother may need more or less). >From that point, I have kept my Sinemet dose unchanged ( because I had previously optimised my dosage of Sinemet) and as I rolled steadily downhill (as we all do) I topped up with another 2 x 250 microgrammes tablets of Permax. In this way, I have virtually stabilised my symptoms for the past 3 years, and I am now taking 2.5 milligrams (That's like 10 of the 250 microgram tablets). The doctors say that Permax is OK up to 4 milligrams, so I have a way to go yet. I must confess that I do not understand the rush to get the latest tablet of the month. A Dopamine agonist can only be expected to a) Substitute for the missing Dopamine, and b) Do it without provoking dyskinesias. Permax does this job pretty well in my experience, so good luck, and I will be interested to see how you get on with it. Regards -- Brian Collins <[log in to unmask]>