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At 08:07 AM 10/27/97 -0500, you wrote: Marcia, I can't give you any prdictions as to how your father will do with Mirapex. I can tell you how it is working for me. I am 54/10 and I am in good health. I was taking 25/100 generic Sinemet at the rate of 1 every two hours and 25/100cr at 1 every three hours. I was still having significant "off" times about one time per day. By significant I mean the "off" lasted at least two hours. I am in my fourth week with Mirepex. I am taking 1/2 of a 1.5 mg pill at six am and the other 1/2 at two pm. Now I am taking the 25/100 generic Sinemet every 2-1/2 hours and about 3 25/100cr. I don't have any times when I am completely "off" except when I get up in the morning. Otherwise I have not had a significant "off" time in the last four weeks. I generally feel better and I think for me the Mirapex is the best thing since sliced bread. It was just what I needed. This may not help much as far as your father is concerned. >I have followed the postings of those who have started Mirapex, and now >my dad's nero would like to start him. Before doing so I would like your >collective good wisdom to put together a list of questions to ask the >doc before we use him as a guinea pig. A little background info: Dad is >80, has had PD for 10+ years. He is on .25 permax, 1 1/2 - 3 times a day, >sinemet 25/250 3 times a day. He has no tremor, major problem is inability >to speak, major swallowing problems(he has had a PEG tube for 1+ years now), >and lots of drooling. He has no dementia and no depression. My concern >with starting a new drug is that he has never been very cognizant of changes >in his body. If you ask him how he feels he always says fine. My mother, >his CG, does not handle any change in the routine well. I'm 60 miles away. >She is not the type who could adjust medication as needed. She just does >what the doc says. The neuro is good, but he is also the "Einstein" type >and starts to glaze over when I quiz him. So I want to fax him my questions >in advance of talking to him. Thanks in advance for your help. >Marcia > > Yours and His David L. Moreland [log in to unmask]