Hi "guys" You may recall my dad was put on Mirapex 3 weeks ok - it went well till week 3 when he was feeling sick again - but then my mom cut back more of the Sinemet (half tablet at noon) - and hes' been doing better (no more depression , nausea, fogginess etc - truely a changed man !) Went to Neuro yesterday - at first he seemed a little annoyed that my mom cut the Sinemet and made some comment about one tablet being worthless - but then he saw my dad was walking better and talking better - and THATS what really counts right ? He was on 1.5mg/day ( or two 0.25 tablets three times a day) ANyway - he's increasing the Mirapex even further - todday he starts on 3 - 0.25 mg tablets - three times a day (for a total of 2.25) - next week he goes to 1- 1mg tablet three times (total of 3 mg) - then the next 1-1mg and 1 -0.25 mg - three times for a total of 3.75 a day. Is all this REALLY necessary ? I thought the therapeutic dose was 1.5mg/day ? What have you guys titrated out at ? Oh and he cut the Sinemet altogether. Just wondering ... Donna ------------------------------------------------------------------------------ - Donna Bassolino-Klimas, Ph.D. Bristol Myers Squibb Pharma. Res. Inst. Department of Macromolecular Structure P.O. Box 4000 Room H3812 Princeton, N.J. 08543 4000 (609) 252 4413 INTERNET: [log in to unmask] ------------------------------------------------------------------------------