Hi-Mel has just the opposite reaction with his sleep patterns. He is now sleeping all night most nights (could be related to his kidney disease i suppose however). I thinking about changing my night aide on the weekends to daytime as I now get enought rest myself. He is on Mirapex .625 three times daily and has cut the sinemet down from 4 50/200 CR to 3 sinemet 25/100CR. He has an antsy time around 4-6pm and I think it may be his 2pm sinemet. Mary CG Mel 76/11 [log in to unmask]