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I've been taking seligilene or deprenyl or eldepryl for 7 years this coming January and have no complaints. My then-neuro told me I was lucky because it hadn't been around very long and was supposed to slow down the worsening of the symptoms. I take two a day, one when I get up and one at lunchtime, along with 1/3 sinemet (25/100s). I've noticed a huge difference in the amounts of sinemet required among those of us who take it. Is it due to sensitivity, stage of progression, or weight? Or what? Liz Don from Lima: I have a friend who is numb from the waist down because of an accident and she wears an alarm watch and 'goes' every hour so she won't have an accident. Might be worth trying until your doctor helps you. Liz