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Emily wrote: The higher dose of Mirapex made him feel so "sick" (I think he means "overmedicated") he dropped back to .75 daily after only a week at the "theraupeutic" dosage. He can handle that OK. Listmembers responded to my concerns and said, essentially, 'why mess with a good thing if it works?'. Now he is right on the edge of needing something more--we don't know what it would be, tho: try upping the Mirapex again? I think it's worth a try--go very slowly. I started Mirapex in mid-August starting with 0.125 mg three times/day. My intention was then to add one pill three times/day each week. I did okay until I hit 2.25 mg/day. I began having headaches and nausea. Advil helped ease the headaches and ginger took care of the nausea, but when I tried increasing again, the headaches and nausea were more than I wanted to live with so I slowed down. I stayed on 2.25 mg/day for two or three weeks, then eased up. I have just started 3.75 mg/day. It is easing the tremor a little, but the tremor is still omnipresent. I wish you success! Joan Dykstra