 |
 |
hi ralph you wrote: >Does Estrogen replacement therapy (ERT) have an adverse effect on PD? >Has anyone had experience with ERT and PD? >Dr Sessions et al in Med Hypothesis 1994 April 42(4): 280-282 refers to >"numerous studies" showing an adverse effect on PD symptoms when ERT was >given. However I can't find any other references for this subject. ralph, you have touched on one of my pet peeves my understanding is that 'numerous studies' is a slight exaggeration i believe that there have been numerous anecdotal reports but pitifully few actual clinical studies i have a slew of info on female hormones and how they affect pd which i could send to you separately if you wish the bottom line for me is that i believe high levels of estrogen virtually wipe out sinemet's effect these high levels can occur predictably during normal menses cycles or erratically during the craziness of hormone swings in menopause or, possibly, by using hrt for example, in re menopausal me, my med/symptom control routine is pretty smooth and predictable with 'off' periods of maybe 15 minutes a couple of times a day however, when estrogen rears its ugly head i can be 'off' for four or five hours at a stretch many times over a period of several days apparently there are one or two med steps that could be attempted to help address this situation [based on no studies, though] but i'm pretty chicken about fooling with my brain chemistry and figure, hey, i got through puberty, i can get through this my impression is that once the estrogen levels drop after menopause there is no longer any interference with the sinemet/levodopa with love to you and yours your cyber-sis janet janet paterson - 50/9 - sinemet/selegiline/prozac - [log in to unmask]