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----------------------------------------------------------------------- Unilateral pallidal stimulation for Parkinson's disease: neurobehavioral functioning before and 3 months after implantation. ----------------------------------------------------------------------- Unilateral pallidotomy is thought to have a low risk for cognitive morbidity. Nonetheless, recent research suggests that some patients experience declines in memory and language and that pallidal stimulation might be a safer treatment for Parkinson's disease (PD). We investigated the neurobehavioral effects of unilateral pallidal stimulation. Nine consecutive PD patients undergoing unilateral deep brain-stimulating electrode implantation in the globus pallidus interna were evaluated with a neuropsychological test battery approximately 1 month before and 3 months after surgery. Patients reported significantly fewer symptoms of anxiety and greater vigor after surgery. There was a trend toward fewer depressive symptoms. Semantic verbal fluency and visuoconstructional test scores declined significantly after surgery. However, among five patients showing declines in semantic verbal fluency, only one patient's score declined by more than 2 SD. No patient showed significant decline or improvement in the overall level of cognitive functioning. This study supports the relative safety, in terms of cognitive function, of unilateral pallidal stimulation in PD. Neurology 1997 Oct;49(4):1078-1083 Troster AI, Fields JA, Wilkinson SB, Pahwa R, Miyawaki E, Lyons KE, Koller WC University of Kansas Medical Center, Kansas City, Kansas, 66160, USA PMID: 9339693, MUID: 97479612 ----------------------------------------------------------------------- janet paterson - 50/9 - sinemet/selegiline/prozac - [log in to unmask]