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Title=20
     A rat model of Parkinson's disease induced by Japanese encephalitis
virus.=20
Author=20
     Ogata A; Tashiro K; Nukuzuma S; Nagashima K; Hall WW=20
Address=20
     Department of Neurology, Hokkaido University School of Medicine,
Kita-ku, Sapporo, Japan.=20
Source=20
     J Neurovirol, 3(2):141-7 1997 Apr=20
Abstract=20
     In Fischer rats infected with Japanese encephalitis virus (JEV) at
13 days after birth and sacrificed 12 weeks later, the
     major pathological changes resembled those found in Parkinson's
disease. Specifically there was neuronal loss with
     gliosis which was confined mainly to the zona compacta of the
substantia nigra, with a notable absence of lesions in the
     cerebral cortex and cerebellum. Changes were bilateral being most
severe in the central part of the zona compacta.
     Immunohistochemical studies with anti-tyrosine hydroxylase (TH)
demonstrated that the number of TH-positive neurons
     was significantly decreased in the substantia nigra compared to
controls, while comparable numbers of TH-positive
     neurons were found in the basal ganglia in both JEV-treated rats
and age-matched controls. JEV-infected rats showed
     marked bradykinesia, with significant behavioral improvement being
observed following administration of L-DOPA.
     Immunohistochemical studies failed to detect JEV antigens in any
region of the rat brain and the JEV genome was
     undetectable in the substantia nigra and the cerebral cortex using
the reverse transcription-polymerase chain reaction
     (RT-PCR). The findings suggest that JEV infection of rats under the
conditions described may serve as a model of virus
     induced Parkinson's Disease.=20
Language=20
     Eng=20
Unique Identifier=20
     97265239=20



MESH Headings=20
     Animal; Antigens, Viral (AN); Basal Ganglia (PA); Biological
Markers; Disease Models, Animal (*); Encephalitis Virus,
     Japanese (GE/IM/IP/PY); Encephalitis, Japanese (*CO/VI); Gliosis
(ET); Nerve Tissue Proteins (AN); Neurons (PA);
     Parkinson Disease (*ET/PA/VI); Rats; Rats, Inbred F344; RNA, Viral
(AN); Substantia Nigra (PA); Tyrosine
     3-Monooxygenase (AN)=20



Publication Type=20
     JOURNAL ARTICLE=20
ISSN=20
     1355-0284=20
Country of Publication=20
     ENGLAND=20


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