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Rae I too have been wondering about the silemce on tolcapone. Is it because it is not approved here so not many in US are taking it. I am 68/12, have been on tolcapone 6 weeks. Saw my neuro yesterday. He want me to increase to the 200mg tablets 3x a day - I have been able to cutthe sinamet I.m taking to 1 and 1/2 25/100 instead of the 6-8 I was taking. I notice a slow period bradykinesia in afternoon hence the increase in tolcapone to perhaps cause more sinamet to be accepted by the brain. On the down side last week I developed the side effect of diahrhea (sp), flatulence etc you describe. This was three weeks after starting tolcapone. Dr. Koller said this is the norm after u take it for awhile. He had no explanation - said the company had spent a lot of money researching it but no answer so far. I will have to decide if the benefits outweigh this inconvenience (g) - so far yes. Would like to hear from more. BTW I got your message 4times so it did go thru to me at least. ***************************************************** Rosemary Paul [log in to unmask] Community Services x3919 *****************************************************