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Brian, Yen and others, Under the microscope there is no apparent brain damage from sinemet. Nonetheless, I would assume there are some brain changes at the receptor sites at least on the molecular level since long term sinemet induces dyskinesia. Therefore it would be assumed that it induces a change which might be classified as brain damage. From the practical standpoint Yen these days PWP usually start off taking a dopamine agonist such as mirapex (pramipexole), bromocryptine or pergolide to start starting sinemet only if the agonist doesn't relieve symptoms thereby delaying the use of and then hopefully the dyskinesia which is induced by sinemet. Charlie Brian Collins wrote: > > On Sun 26 Oct, Yen Hau wrote: > > Dear Sir, > > Will Sinemet causing any brain damage for long term taking?If > > yes, which part of brain? > > > > Sincerely, > > YEN > > > Hello Yen, I am not aware of any reports of actual brain damage occurring > caused by Sinemet. I would not expect Sinemet to cause damage, because it > is only introducing chemical compounds which are already present. In addition > to that, I have asked a pathologist who is very experienced in examining > the brains of people who have died with Parkinson's Disease, and he told me > that there was no visible difference between those who took Sinemet, and > those who did not take Sinemet. > I hope that answers your question. > > Regards, > -- > Brian Collins <[log in to unmask]> -- CHARLES T. MEYER, M.D. Middleton, WI [log in to unmask]