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oN 10/29 Brian inquired: >>> Brian Collins <[log in to unmask]> 10/29/97 04:32am >>> >>> Maybe Stephan or Janet can answer this question: seem to recollect that most of the reports that come along deal mostly with Selegiline in combination with Levodopa. Are there any dealing with Selegiline as the only input ?<<< Good evening Brian: Quick answer - yes. In Neurology, February 1996, v.46No.2, a team of researchers conducted a study of the effects of selegiline alone and in combination with bromocriptine (Parlodel). It was called the PARJUPAR STUDY, in Portugal, by A. Castro-Caldas. The study lasted three years and found that both (individually and together) meds have a beneficial effect in delaying the need for levodopa therapy. The researchers would not go so far as to opine that selegiline exhibited a neuroprotective effect, but they did report a lessening of PD symptoms, thereby delaying or sparing the need for levodopa. Stephan 53/7