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About a month or so ago someone wrote that they reacted differently to their PD medication when they ate grapefruit. Abigail Zuger, writing for the NY Times, says: "Researchers have known since 1989 that when some of the common blood-pressure pills were washed down with grapefruit juice , far moreof the drug reached the blood than when they were taken with water instead......The handful of drugs now known to be involved include...Plendil for high blood pressure, seldane for allergies.....et al. .... What these drugs have in common is their fate after they pass through the stomach. Unlike other drugs that are absorbed directly from the intestine into the blood stream, these are first broken down by an enzyme in the small intestine....grapefruit juice appeared to remove large amounts of that enzyme from the intestinal wall....the amount of enzyme in the intestinal wall varies greatly among people ..which explains why the grapefruit effect may be serious for some people and unimportant for others." Perhaps the PD drugs are among those that are in this class.???? [log in to unmask]