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what dosage are you taking of Requip? What other drugs are you taking? Thanks for the info. -----Original Message----- From: Jack Stanfield <[log in to unmask]> To: Multiple recipients of list PARKINSN <[log in to unmask]> Date: Tuesday, November 04, 1997 12:09 AM Subject: Re: Requip//Mirapex >I have been reading the posts on Mirapex and, of course, those on Sinemet. > As a member of the experimental group on Ropinerole (Requip) for 3+ years, I >can say that none of those problems have afflicted me. Requip has been a >wonderful drug for me and I encourage all of you to discuss it with your >neuro. As I have noted before, there is the school of thought that maintains >that Sinemet overworks the substantia nigra (sp?) until it finally loses the >last 20% of its existence and then the problems of on/off begin because there >is no natural source for dopamine. The theory is that the agonists do not do >this and allow you to retain enough dopamine producing sources so as to avoid >on/off. True? I don't know. But I do know that I have had none of the >on/off problems to date and am still viewed as mild -- although the disease >marches on inexorably for all of us (drooling now}. In any event, I vote for >Requip. [log in to unmask] (Lararmie, Wyo.)