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Hi: This is my first attempt to send a note to this list. I hope it works. I am the caregiver for my wife Carline who recently added Symetrel and Parlodel to her prescriptions of Sinemet Cr and Eldepryl. She developed terrible Edema (swelling) around her ankles which then spread to her feet and lower calf. Contraindications for Symetrel are "swollen ankles" but the Neuro said: That's not it. I am not so sure and asked her to stop taking Symetrel and the Parlodel about two weeks ago. The swelling has not really gone down so they looked for a clogged vein with Ultrasound (Doppler) but found nothing. Has anybody else experienced strong swollen ankles? It seems to take too long to go down. Thanks, K-F CG for Carline (73/5)