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On Tue 04 Nov, Karl-Friedrich Etzold wrote: > Hi: > This is my first attempt to send a note to this list. I hope it works. > > I am the caregiver for my wife Carline who recently added Symetrel and > Parlodel to her prescriptions of Sinemet Cr and Eldepryl. She developed > terrible Edema (swelling) around her ankles which then spread to her feet > and lower calf. Contraindications for Symetrel are "swollen ankles" > but the Neuro said: That's not it. I am not so sure and asked her to stop > taking Symetrel and the Parlodel about two weeks ago. The swelling has > not really gone down so they looked for a clogged vein with Ultrasound > (Doppler) but found nothing. Has anybody else experienced strong > swollen ankles? It seems to take too long to go down. > Thanks, > K-F CG for Carline (73/5) > > > Hello Karl, It is difficult to suggest which of your wife's drugs may be to blame for the swelling. What I would say however is that both Parlodel and Symetrel are what you might call 'Old Tech'. The more modern Dopamine agonists all behave in a similar way, butare much less likely to provoke secondary effects, like your wife's swollen ankles. There is not a direct modern equivalent for Symetrel, It is just not used that much any more. My advice is to suggest a newer Dopamine agonist: Permax, Re-Quip, or Cabergoline. -- Brian Collins <[log in to unmask]>