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Barbara Mallut wrote: > > Well, m'friends, I've been on Mirapex for over 2 months, and while there was > one very noticeable benefit - less of the grinding fatigue I had suffered from > nearly every day - the side effects from just a 1/2 of a 0.25 mg tablet taken > 3 times daily were unbearable - AND unnecessary for me to live with. > > While I've certainly had PD symptoms since my unilateral pallidotomy 3 years > ago, dyskenesia, wasn't one of them. Also, Sinemet worked for me (except for > not stopping the fatigue) over the course of the average day with no "on and > off" times since the surgery. I was always "on," tho did get a vague, > "antsy" feeling if too much time had passed since my last dose of Sinemet. > > The longer I took the Mirapex (and experimented with both lower and > normal-for-me daily dose of that drug) the more dyskenesia I was getting from > late afternoon and into the evening, plus once again, I began having > "on/offs." > > Do I NEED this? Nope! So today I've stopped taking any Mirapex. > > Adios Mirapex... hello again, profound fatigue <groan> WHAT a miserable > choice to have to make! > > Barb Mallut > [log in to unmask] Dear Barb: Sorry to hear about your problems with Miripex. You might try Ropinerole, which was approved about 2 weeks ago. It is a Dopamine Agonist also, but might be better than Mirapex. Only a trial will tell. I would like to get feedback from the list from PWP who have not done well on one of the new agonists but have done well on the other. I realize this will take a little time and your cooperation will be appreciated. Jerry Starr