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On Wed 29 Oct, Charles T. Meyer wrote: > Brian, Yen and others, > > Under the microscope there is no apparent brain damage from sinemet. > Nonetheless, I would assume there are some brain changes at the > receptor sites at least on the molecular level since long term sinemet > induces dyskinesia. Therefore it would be assumed that it induces a > change which might be classified as brain damage. From the practical > standpoint Yen these days PWP usually start off taking a dopamine > agonist such as mirapex (pramipexole), bromocryptine or pergolide to > start starting sinemet only if the agonist doesn't relieve symptoms > thereby delaying the use of and then hopefully the dyskinesia which is > induced by sinemet. > > Charlie > > CHARLES T. MEYER, M.D. > Middleton, WI > [log in to unmask] > > > Hello Charlie, I am disappointed: after all that has been written in these columns, do you still subscribe to that nonsense about 'delaying the start of levodopa therapy' Regards, -- Brian Collins <[log in to unmask]>