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Dear Helen! I do have similar experience with Permax as your husband. I was also on permax 3 mg/day. After I started with Permax for 1=BD year ago, my ankles= appeared more swollen than before. My body/face color is redder than normal only than I am drowsy after the madication. = Drowsiness was/is my big problem. It used to appear about 1 hour after taking Permax. My neuro told me that the sideeffects appeared us a result of to high blood concentration of Permax 1 hour after medication. I have reduced Permax to 2=BD mg/day, with 1 mg in the morning and =BD mg= x 4 the rest of the day. I am feeling much better! Conclusion: It is better to take Permax =BD mg x 6, than 1 mg x 3. Swollen ankles: Check the heart and try to move your legs more. Reduced muscle activity may also leed to swollen ankles. I wish you all the best. Hallvard